This layout includes two humbucker pickups, which are positioned at the central pickup and bridge pickup locations of the guitar.

The Humbucker pickups offer better response to low frequencies and bass sound, as well as greater resistance to noise. This makes the guitar suitable for powerful riffs and solos.

Equipped with passive pickups, which do not require external power to operate. Specifically, the passive pickups work using magnetism and produce a signal that is inversely proportional to the movement of the strings.

The PRS SE Santana has a "double-cutaway" or "double-cut" body shape, meaning it has two cutaways on the upper and lower sides of the body to provide easier access to the higher frets. This shape is iconic for PRS Guitars and characterizes many of its models.