Ezio returns and fights against the powerful Templar Order. Now, as a legendary Master Assassin, he must travel to Rome, the center of power, greed, and corruption, in order to strike at the heart of the enemy. Ezio will lead an entire Brotherhood, which will rally beside him, and only by working together can the Assassins defeat their mortal enemies.

Assassin's Creed Brotherhood also offers a completely innovative multiplayer element, in which players will be able to assist the Templars, using Abstergo to train in the art of assassination, so as to eliminate the Assassins once and for all. Players will have the ability to choose from a range of unique characters - each with their own weapons and distinct assassination techniques - and combine their skills against other players from around the world in different game modes.